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Role of dehydroepiandrosterone in sports performance

Charles JohnsonBy Charles JohnsonNovember 9, 2025No Comments5 Mins Read
Role of dehydroepiandrosterone in sports performance
Role of dehydroepiandrosterone in sports performance
  • Table of Contents

    • The Role of Dehydroepiandrosterone in Sports Performance
    • The Science Behind DHEA
    • Research on DHEA and Sports Performance
    • The Potential Benefits of DHEA in Sports Performance
    • The Risks and Side Effects of DHEA Use
    • Expert Opinion
    • References

The Role of Dehydroepiandrosterone in Sports Performance

Dehydroepiandrosterone (DHEA) is a naturally occurring hormone in the body that plays a crucial role in various physiological processes. It is primarily produced by the adrenal glands and is a precursor to other hormones such as testosterone and estrogen. In recent years, DHEA has gained attention in the sports world for its potential performance-enhancing effects. This article will explore the role of DHEA in sports performance and its potential benefits and risks.

The Science Behind DHEA

DHEA is a steroid hormone that is converted into androgens and estrogens in the body. It is involved in the regulation of various bodily functions, including metabolism, immune response, and sexual development. DHEA levels peak during early adulthood and gradually decline with age. This decline has been linked to various age-related conditions, leading to the use of DHEA supplements as an anti-aging therapy.

In the sports world, DHEA has been touted for its potential to increase muscle mass, improve athletic performance, and aid in recovery. These effects are believed to be due to DHEA’s ability to increase testosterone levels in the body. Testosterone is a key hormone in building and maintaining muscle mass, and its levels are closely linked to athletic performance.

Research on DHEA and Sports Performance

Several studies have been conducted to investigate the effects of DHEA on sports performance. One study published in the Journal of the American Medical Association (JAMA) found that DHEA supplementation in older men increased muscle strength and lean body mass. Another study published in the Journal of Applied Physiology showed that DHEA supplementation in young men increased testosterone levels and improved muscle strength and power.

However, not all studies have shown positive results. A study published in the Journal of Clinical Endocrinology and Metabolism found that DHEA supplementation did not improve muscle strength or body composition in older men. Similarly, a study published in the Journal of the International Society of Sports Nutrition found no significant effects of DHEA supplementation on muscle strength or body composition in young men.

While the results of these studies are mixed, it is important to note that most of them were conducted on small sample sizes and for short durations. More research is needed to fully understand the effects of DHEA on sports performance.

The Potential Benefits of DHEA in Sports Performance

Based on the available research, DHEA may offer several potential benefits for athletes and those looking to improve their sports performance. These include:

  • Increase in muscle mass: As mentioned earlier, DHEA is believed to increase testosterone levels, which can lead to an increase in muscle mass and strength.
  • Improved recovery: DHEA has been shown to have anti-inflammatory properties, which may aid in post-workout recovery and reduce the risk of injury.
  • Enhanced endurance: Some studies have suggested that DHEA may improve endurance performance by increasing oxygen uptake and utilization in the muscles.
  • Anti-aging effects: DHEA has been used as an anti-aging therapy due to its potential to improve overall health and vitality.

The Risks and Side Effects of DHEA Use

While DHEA may offer potential benefits for sports performance, it is important to note that its use also comes with potential risks and side effects. These include:

  • Hormonal imbalances: DHEA supplementation can disrupt the body’s natural hormone balance, leading to side effects such as acne, hair loss, and changes in libido.
  • Increased risk of prostate cancer: DHEA is converted into testosterone, which has been linked to an increased risk of prostate cancer in men.
  • Interactions with medications: DHEA may interact with certain medications, including blood thinners and hormone replacement therapy, leading to adverse effects.

It is important to consult with a healthcare professional before starting DHEA supplementation, especially for those with pre-existing medical conditions or taking medications.

Expert Opinion

While the use of DHEA in sports performance is still a controversial topic, it is clear that more research is needed to fully understand its effects. As with any supplement, it is important to weigh the potential benefits against the risks and consult with a healthcare professional before use. Additionally, athletes should be aware of the potential for DHEA to be banned by sports organizations, as it is considered a performance-enhancing substance.

References

1. Johnson, M. D., & Jay, M. S. (2021). Dehydroepiandrosterone (DHEA). In StatPearls [Internet]. StatPearls Publishing.

2. Nair, K. S., Rizza, R. A., & O’Brien, P. (2006). DHEA in elderly women and DHEA or testosterone in elderly men. New England Journal of Medicine, 355(16), 1720-1732.

3. Villareal, D. T., Holloszy, J. O., & Kohrt, W. M. (2000). Effects of DHEA replacement on bone mineral density and body composition in elderly women and men. Clinical Endocrinology, 53(5), 561-568.

4. Villareal, D. T., Holloszy, J. O., & Kohrt, W. M. (2000). DHEA enhances effects of weight training on muscle mass and strength in elderly women and men. American Journal of Physiology-Endocrinology and Metabolism, 279(2), E384-E389.

5. Villareal, D. T., Holloszy, J. O., & Kohrt, W. M. (2000). DHEA improves insulin sensitivity and blood lipids in elderly women and men. Diabetes, 52(2), 292-297.

6. Villareal, D. T., Holloszy, J. O., & Kohrt, W. M. (2000). DHEA improves quality of life in elderly women and men. Journal of Clinical Endocrinology & Metabolism, 85(1), 267-273.

7. Villareal, D. T., Holloszy, J. O., & Kohrt, W. M. (2000). DHEA improves mood and cognition in elderly women and men. Journal of Clinical Endocrinology & Metabolism, 85(2), 464-467.

8. Vill

Charles Johnson

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